1xbn

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[[Image:1xbn.gif|left|200px]]
[[Image:1xbn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xbn |SIZE=350|CAPTION= <scene name='initialview01'>1xbn</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1xbn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Tar4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 Thermoanaerobacter tengcongensis])
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|DOMAIN=
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{{STRUCTURE_1xbn| PDB=1xbn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbn OCA], [http://www.ebi.ac.uk/pdbsum/1xbn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xbn RCSB]</span>
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'''Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain'''
'''Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain'''
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[[Category: Nioche, P.]]
[[Category: Nioche, P.]]
[[Category: Raman, C S.]]
[[Category: Raman, C S.]]
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[[Category: cgmp]]
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[[Category: Cgmp]]
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[[Category: heme protein]]
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[[Category: Heme protein]]
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[[Category: nitric oxide]]
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[[Category: Nitric oxide]]
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[[Category: soluble guanylyl cyclase]]
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[[Category: Soluble guanylyl cyclase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:49:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:47:24 2008''
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Revision as of 11:49, 3 May 2008

Image:1xbn.gif


PDB ID 1xbn

Drag the structure with the mouse to rotate
1xbn, resolution 2.50Å ()
Ligands: ,
Gene: Tar4 (Thermoanaerobacter tengcongensis MB4)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain


Overview

Nitric oxide (NO) is extremely toxic to Clostridium botulinum, but its molecular targets are unknown. Here, we identify a heme protein sensor (SONO) that displays femtomolar affinity for NO. The crystal structure of the SONO heme domain reveals a previously undescribed fold and a strategically placed tyrosine residue that modulates heme-nitrosyl coordination. Furthermore, the domain architecture of a SONO ortholog cloned from Chlamydomonas reinhardtii indicates that NO signaling through cyclic guanosine monophosphate arose before the origin of multicellular eukaryotes. Our findings have broad implications for understanding bacterial responses to NO, as well as for the activation of mammalian NO-sensitive guanylyl cyclase.

About this Structure

1XBN is a Single protein structure of sequence from Thermoanaerobacter tengcongensis. Full crystallographic information is available from OCA.

Reference

Femtomolar sensitivity of a NO sensor from Clostridium botulinum., Nioche P, Berka V, Vipond J, Minton N, Tsai AL, Raman CS, Science. 2004 Nov 26;306(5701):1550-3. Epub 2004 Oct 7. PMID:15472039 Page seeded by OCA on Sat May 3 14:49:21 2008

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