1xcs
From Proteopedia
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[[Image:1xcs.gif|left|200px]] | [[Image:1xcs.gif|left|200px]] | ||
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'''structure of oligonucleotide/drug complex''' | '''structure of oligonucleotide/drug complex''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. | |
==Reference== | ==Reference== | ||
Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15926069 15926069] | Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15926069 15926069] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Murshudov, G N.]] | [[Category: Murshudov, G N.]] | ||
[[Category: Steiner, R A.]] | [[Category: Steiner, R A.]] | ||
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[[Category: Valls, N.]] | [[Category: Valls, N.]] | ||
[[Category: Wright, G.]] | [[Category: Wright, G.]] | ||
| - | [[Category: | + | [[Category: Co2+]] |
| - | [[Category: | + | [[Category: Double helix]] |
| - | [[Category: | + | [[Category: Drug-dna complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:51:51 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:51, 3 May 2008
structure of oligonucleotide/drug complex
Overview
The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.
About this Structure
Full crystallographic information is available from OCA.
Reference
Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:15926069 Page seeded by OCA on Sat May 3 14:51:51 2008
