5qc7

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m (Protected "5qc7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5qc7 is ON HOLD
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==Crystal structure of human Cathepsin-S with bound ligand==
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<StructureSection load='5qc7' size='340' side='right' caption='[[5qc7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Yang, H., Shao, C., Burley, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5qc7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QC7 FirstGlance]. <br>
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Description: Ligand binding to Cathepsin S
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQS:2-[1-(cyclohexylmethyl)piperidin-4-yl]-1-{3-[3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-4-(trifluoromethyl)phenyl]-1-propyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one'>BQS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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[[Category: Burley, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qc7 OCA], [http://pdbe.org/5qc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qc7 RCSB], [http://www.ebi.ac.uk/pdbsum/5qc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qc7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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__TOC__
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</StructureSection>
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[[Category: Cathepsin S]]
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[[Category: Ameriks, M K]]
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[[Category: Bembenek, S D]]
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[[Category: Burley, S K]]
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[[Category: Mirzadegan, T]]
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[[Category: Shao, C]]
[[Category: Yang, H]]
[[Category: Yang, H]]
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[[Category: Shao, C]]
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[[Category: Cathepsin s]]
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[[Category: D3r]]
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[[Category: Hydrolase]]
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[[Category: Ligand docking]]

Revision as of 06:14, 20 December 2017

Crystal structure of human Cathepsin-S with bound ligand

5qc7, resolution 1.90Å

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