This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5qcd
From Proteopedia
(Difference between revisions)
m (Protected "5qcd" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Cathepsin-S with bound ligand== | |
| - | + | <StructureSection load='5qcd' size='340' side='right' caption='[[5qcd]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qcd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BHJ:{(3S)-7-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}(piperidin-1-yl)methanone'>BHJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr> |
| - | [[Category: Burley, S]] | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qcd OCA], [http://pdbe.org/5qcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qcd RCSB], [http://www.ebi.ac.uk/pdbsum/5qcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qcd ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cathepsin S]] | ||
| + | [[Category: Ameriks, M K]] | ||
| + | [[Category: Bembenek, S D]] | ||
| + | [[Category: Burley, S K]] | ||
| + | [[Category: Mirzadegan, T]] | ||
| + | [[Category: Shao, C]] | ||
[[Category: Yang, H]] | [[Category: Yang, H]] | ||
| - | [[Category: | + | [[Category: Cathepsin s]] |
| + | [[Category: D3r]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Ligand docking]] | ||
Revision as of 06:14, 20 December 2017
Crystal structure of human Cathepsin-S with bound ligand
| |||||||||||
Categories: Cathepsin S | Ameriks, M K | Bembenek, S D | Burley, S K | Mirzadegan, T | Shao, C | Yang, H | Cathepsin s | D3r | Hydrolase | Ligand docking
