1xdt
From Proteopedia
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[[Image:1xdt.gif|left|200px]] | [[Image:1xdt.gif|left|200px]] | ||
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'''COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR''' | '''COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR''' | ||
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[[Category: Corynebacterium diphtheriae]] | [[Category: Corynebacterium diphtheriae]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: NAD(+)--diphthamide ADP-ribosyltransferase]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bowman, M E.]] | [[Category: Bowman, M E.]] | ||
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[[Category: Louie, G V.]] | [[Category: Louie, G V.]] | ||
[[Category: Yang, W.]] | [[Category: Yang, W.]] | ||
| - | [[Category: | + | [[Category: Diphtheria toxin]] |
| - | [[Category: | + | [[Category: Epidermal growth factor]] |
| - | + | [[Category: Heparin-binding epidermal growth factor]] | |
| - | [[Category: | + | [[Category: Receptor]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:53:59 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:54, 3 May 2008
COMPLEX OF DIPHTHERIA TOXIN AND HEPARIN-BINDING EPIDERMAL GROWTH FACTOR
Overview
We describe the crystal structure at 2.65 A resolution of diphtheria toxin (DT) complexed 1:1 with a fragment of its cell-surface receptor, the precursor of heparin-binding epidermal-growth-factor-like growth factor (HBEGF). HBEGF in the complex has the typical EGF-like fold and packs its principal beta hairpin against the face of a beta sheet in the receptor-binding domain of DT. The interface has a predominantly hydrophobic core, and polar interactions are formed at the periphery. The structure of the complex suggests that part of the membrane anchor of the receptor can interact with a hinge region of DT. The toxin molecule is thereby induced to form an open conformation conducive to membrane insertion. The structure provides a basis for altering the binding specificity of the toxin, and may also serve as a model for other EGF-receptor interactions.
About this Structure
1XDT is a Protein complex structure of sequences from Corynebacterium diphtheriae and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor., Louie GV, Yang W, Bowman ME, Choe S, Mol Cell. 1997 Dec;1(1):67-78. PMID:9659904 Page seeded by OCA on Sat May 3 14:53:59 2008
