1xe3

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[[Image:1xe3.jpg|left|200px]]
[[Image:1xe3.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1xe3 |SIZE=350|CAPTION= <scene name='initialview01'>1xe3</scene>, resolution 2.24&Aring;
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The line below this paragraph, containing "STRUCTURE_1xe3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= deoD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
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-->
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|DOMAIN=
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{{STRUCTURE_1xe3| PDB=1xe3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe3 OCA], [http://www.ebi.ac.uk/pdbsum/1xe3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xe3 RCSB]</span>
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}}
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'''Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis'''
'''Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis'''
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[[Category: Wilkinson, A J.]]
[[Category: Wilkinson, A J.]]
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
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[[Category: deod]]
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[[Category: Deod]]
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[[Category: purine nucleoside phosphorylase]]
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[[Category: Purine nucleoside phosphorylase]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:14:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:48:20 2008''
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Revision as of 05:14, 13 April 2008

Image:1xe3.jpg

Template:STRUCTURE 1xe3

Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis


Overview

Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.

About this Structure

1XE3 is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068 Page seeded by OCA on Sun Apr 13 08:14:13 2008

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