5un1

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'''Unreleased structure'''
 
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The entry 5un1 is ON HOLD until Paper Publication
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==Crystal structure of GluN1/GluN2B delta-ATD NMDA receptor==
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<StructureSection load='5un1' size='340' side='right' caption='[[5un1]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5un1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UN1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMK:(5S,10R)-5-METHYL-10,11-DIHYDRO-5H-5,10-EPIMINODIBENZO[A,D][7]ANNULENE'>BMK</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5un1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5un1 OCA], [http://pdbe.org/5un1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5un1 RCSB], [http://www.ebi.ac.uk/pdbsum/5un1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5un1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NMDZ1_XENLA NMDZ1_XENLA]] Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:16214956, PubMed:19524674, PubMed:21677647, PubMed:25008524, PubMed:26912815, PubMed:27135925, Ref.11, PubMed:28232581). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable).<ref>PMID:16214956</ref> <ref>PMID:19524674</ref> <ref>PMID:21677647</ref> <ref>PMID:25008524</ref> <ref>PMID:26912815</ref> <ref>PMID:27135925</ref> <ref>PMID:28232581</ref> [PDB:5IOV]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gouaux, E]]
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[[Category: Song, X]]
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[[Category: Arrangement]]
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[[Category: Channel blocker]]
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[[Category: Complex]]
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[[Category: Membrane proteins-inhibitor complex]]

Revision as of 06:12, 7 February 2018

Crystal structure of GluN1/GluN2B delta-ATD NMDA receptor

5un1, resolution 3.60Å

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