5v5o
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha== | |
| - | + | <StructureSection load='5v5o' size='340' side='right' caption='[[5v5o]], [[Resolution|resolution]] 2.24Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5v5o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zdu|4zdu]], [[5v5p|5v5p]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5o OCA], [http://pdbe.org/5v5o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5o RCSB], [http://www.ebi.ac.uk/pdbsum/5v5o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5o ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Cingolani, G]] | [[Category: Cingolani, G]] | ||
| + | [[Category: Lokareddy, R K]] | ||
| + | [[Category: Sankhala, R S]] | ||
| + | [[Category: Nl]] | ||
| + | [[Category: Nuclear import]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 06:23, 14 March 2018
Structure of NLS2K of influenza A virus nucleoprotein bound to importin alpha
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