1kct
From Proteopedia
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==Overview== | ==Overview== | ||
The crystal structure of a recombinant human alpha 1-antitrypsin, in the, uncleaved and uncomplexed state, has been determined by X-ray, crystallographic methods and refined to an R-factor of 18.4% for 8.0-3.46, A data with good stereochemistry. This structure provides the first view, at the inhibitory loop and the central beta-sheet A of the uncleaved alpha, 1-antitrypsin. The reactive loop takes a distorted helical conformation, and no pre-insertion of two residues in the reactive loop into the, beta-sheet A is observed. The present structure is largely in agreement, with the model predicted by Engh, Wright, and Huber [Prot. Eng. 3 (1990), 469-477]. | The crystal structure of a recombinant human alpha 1-antitrypsin, in the, uncleaved and uncomplexed state, has been determined by X-ray, crystallographic methods and refined to an R-factor of 18.4% for 8.0-3.46, A data with good stereochemistry. This structure provides the first view, at the inhibitory loop and the central beta-sheet A of the uncleaved alpha, 1-antitrypsin. The reactive loop takes a distorted helical conformation, and no pre-insertion of two residues in the reactive loop into the, beta-sheet A is observed. The present structure is largely in agreement, with the model predicted by Engh, Wright, and Huber [Prot. Eng. 3 (1990), 469-477]. | ||
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| + | ==Disease== | ||
| + | Known diseases associated with this structure: Emphysema OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107400 107400]], Emphysema-cirrhosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107400 107400]], Hemorrhagic diathesis due to antithrombin Pittsburgh OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107400 107400]], Pulmonary disease, chronic obstructive, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107400 107400]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: serpin]] | [[Category: serpin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:49:57 2007'' |
Revision as of 15:43, 12 November 2007
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ALPHA1-ANTITRYPSIN
Contents |
Overview
The crystal structure of a recombinant human alpha 1-antitrypsin, in the, uncleaved and uncomplexed state, has been determined by X-ray, crystallographic methods and refined to an R-factor of 18.4% for 8.0-3.46, A data with good stereochemistry. This structure provides the first view, at the inhibitory loop and the central beta-sheet A of the uncleaved alpha, 1-antitrypsin. The reactive loop takes a distorted helical conformation, and no pre-insertion of two residues in the reactive loop into the, beta-sheet A is observed. The present structure is largely in agreement, with the model predicted by Engh, Wright, and Huber [Prot. Eng. 3 (1990), 469-477].
Disease
Known diseases associated with this structure: Emphysema OMIM:[107400], Emphysema-cirrhosis OMIM:[107400], Hemorrhagic diathesis due to antithrombin Pittsburgh OMIM:[107400], Pulmonary disease, chronic obstructive, susceptibility to OMIM:[107400]
About this Structure
1KCT is a Single protein structure of sequence from Homo sapiens. Structure known Active Site: P1. Full crystallographic information is available from OCA.
Reference
Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop., Song HK, Lee KN, Kwon KS, Yu MH, Suh SW, FEBS Lett. 1995 Dec 18;377(2):150-4. PMID:8543039
Page seeded by OCA on Mon Nov 12 17:49:57 2007
