5w9q

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m (Protected "5w9q" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5w9q is ON HOLD until Jun 23 2019
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==Zinc finger region of MBD1 in complex with CpG DNA==
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<StructureSection load='5w9q' size='340' side='right' caption='[[5w9q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Liu, K., Xu, C., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w9q]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W9Q FirstGlance]. <br>
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Description: Zinc finger region of MBD1 in complex with CpG DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w9q OCA], [http://pdbe.org/5w9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w9q RCSB], [http://www.ebi.ac.uk/pdbsum/5w9q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w9q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MBD1_HUMAN MBD1_HUMAN]] Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.<ref>PMID:9207790</ref> <ref>PMID:10454587</ref> <ref>PMID:9774669</ref> <ref>PMID:10648624</ref> <ref>PMID:12711603</ref> <ref>PMID:12665582</ref> <ref>PMID:12697822</ref> <ref>PMID:14610093</ref> <ref>PMID:15327775</ref> <ref>PMID:14555760</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
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[[Category: Liu, K]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Walker, J.R]]
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[[Category: Structural genomic]]
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[[Category: Bountra, C]]
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[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Walker, J R]]
[[Category: Xu, C]]
[[Category: Xu, C]]
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[[Category: Liu, K]]
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[[Category: Cxxc3]]
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[[Category: Edwards, A.M]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Dna-binding]]
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[[Category: Sgc]]
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[[Category: Zinc finger]]

Revision as of 07:17, 18 October 2017

Zinc finger region of MBD1 in complex with CpG DNA

5w9q, resolution 1.80Å

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OCA

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