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5w9s

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m (Protected "5w9s" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5w9s is ON HOLD until Jun 23 2019
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==Zinc finger of human CXXC5 in complex with CpG DNA==
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<StructureSection load='5w9s' size='340' side='right' caption='[[5w9s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Liu, K., Xu, C., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w9s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W9S FirstGlance]. <br>
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Description: Zinc finger of human CXXC5 in complex with CpG DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w9s OCA], [http://pdbe.org/5w9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w9s RCSB], [http://www.ebi.ac.uk/pdbsum/5w9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w9s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CXXC5_HUMAN CXXC5_HUMAN]] May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).<ref>PMID:19182210</ref> <ref>PMID:19557330</ref> <ref>PMID:23303788</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
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[[Category: Liu, K]]
[[Category: Min, J]]
[[Category: Min, J]]
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[[Category: Walker, J.R]]
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[[Category: Structural genomic]]
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[[Category: Bountra, C]]
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[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Walker, J R]]
[[Category: Xu, C]]
[[Category: Xu, C]]
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[[Category: Liu, K]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Edwards, A.M]]
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[[Category: Sgc]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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Revision as of 07:17, 18 October 2017

Zinc finger of human CXXC5 in complex with CpG DNA

5w9s, resolution 2.10Å

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