5wc9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Pit-1 and 4xCATT DNA complex== | |
| - | + | <StructureSection load='5wc9' size='340' side='right' caption='[[5wc9]], [[Resolution|resolution]] 3.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wc9]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WC9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wc9 OCA], [http://pdbe.org/5wc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wc9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wc9 ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/PIT1_HUMAN PIT1_HUMAN]] Hypothyroidism due to deficient transcription factors involved in pituitary development or function;Combined pituitary hormone deficiencies, genetic forms. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PIT1_HUMAN PIT1_HUMAN]] Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202).<ref>PMID:22010633</ref> <ref>PMID:26612202</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Agarwal, S]] | [[Category: Agarwal, S]] | ||
| + | [[Category: Cho, T Y]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna-protein complex]] | ||
| + | [[Category: Transcription regulation]] | ||
Revision as of 07:44, 22 November 2017
Human Pit-1 and 4xCATT DNA complex
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