1xj9

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[[Image:1xj9.jpg|left|200px]]
[[Image:1xj9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1xj9 |SIZE=350|CAPTION= <scene name='initialview01'>1xj9</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1xj9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=APN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-ADENINE'>APN</scene>, <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1xj9| PDB=1xj9 | SCENE= }}
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|RELATEDENTRY=[[1pup|1PUP]], [[1pdt|1PDT]], [[1pnn|1PNN]], [[176d|176D]], [[1nr8|1NR8]], [[1rru|1RRU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xj9 OCA], [http://www.ebi.ac.uk/pdbsum/1xj9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xj9 RCSB]</span>
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}}
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'''Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network'''
'''Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network'''
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==About this Structure==
==About this Structure==
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1XJ9 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XJ9 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XJ9 OCA].
==Reference==
==Reference==
Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network., Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS, J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15686374 15686374]
Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network., Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS, J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15686374 15686374]
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[[Category: Protein complex]]
 
[[Category: Gajhede, M.]]
[[Category: Gajhede, M.]]
[[Category: Kastrup, J S.]]
[[Category: Kastrup, J S.]]
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[[Category: Petersson, B.]]
[[Category: Petersson, B.]]
[[Category: Rasmussen, H.]]
[[Category: Rasmussen, H.]]
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[[Category: duplex-triplex complex]]
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[[Category: Duplex-triplex complex]]
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[[Category: left-handed]]
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[[Category: Left-handed]]
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[[Category: partly self-complementary]]
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[[Category: Partly self-complementary]]
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[[Category: peptide nucleic acid]]
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[[Category: Peptide nucleic acid]]
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[[Category: pna]]
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[[Category: Pna]]
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[[Category: right-handed]]
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[[Category: Right-handed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:06:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:50:20 2008''
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Revision as of 12:06, 3 May 2008

Image:1xj9.jpg

Template:STRUCTURE 1xj9

Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network


Overview

The X-ray structure of a partly self-complementary peptide nucleic acid (PNA) decamer (H-GTAGATCACT-l-Lys-NH(2)) to 2.60 A resolution is reported. The structure is mainly controlled by the canonical Watson-Crick base pairs formed by the self-complementary stretch of four bases in the middle of the decamer (G(4)A(5)T(6)C(7)). One right- and one left-handed Watson-Crick duplex are formed. The two PNA units C(9)T(10) change helical handedness, so that each PNA strand contains both a right- and a left-handed section. The changed handedness in C(9)T(10) allows formation of Hoogsteen hydrogen bonding between C(9)T(10) and G(4)A(5) of a PNA strand in an adjacent Watson-Crick double helix of the same handedness. Thereby, a PNA-PNA-PNA triplex is formed. The PNA unit A(3) forms a noncanonical base pair with A(8) in a symmetry-related strand of opposite handedness; the base pair is of the A-A reverse Hoogsteen type. The structural diversity of this PNA demonstrates how the PNA backbone is able to adapt to structures governed by the stacking and hydrogen-bonding interactions between the nucleobases. The crystal structure further shows how PNA oligomers containing limited sequence complementarity may form complex hydrogen-bonding networks.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network., Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS, J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:15686374 Page seeded by OCA on Sat May 3 15:06:03 2008

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