5wh6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5wh6" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5wh6 is ON HOLD until Paper Publication
+
==Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)==
-
 
+
<StructureSection load='5wh6' size='340' side='right' caption='[[5wh6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
Authors: Ke, H., Wang, H.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5wh6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WH6 FirstGlance]. <br>
-
Description: Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKJ:1-[4-(difluoromethoxy)-3-{[(3S)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one'>AKJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wh6 OCA], [http://pdbe.org/5wh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wh6 RCSB], [http://www.ebi.ac.uk/pdbsum/5wh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wh6 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
 +
[[Category: Ke, H]]
[[Category: Wang, H]]
[[Category: Wang, H]]
-
[[Category: Ke, H]]
+
[[Category: Hydrolase-hydrolase inhibitor complex]]
 +
[[Category: Inhibitor zl-n-91]]
 +
[[Category: Pde4d-s91 complex]]
 +
[[Category: Phosphodiesterase]]

Revision as of 07:28, 18 July 2018

Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)

5wh6, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5wh6"
Personal tools