5wiv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride== | |
| - | + | <StructureSection load='5wiv' size='340' side='right' caption='[[5wiv]], [[Resolution|resolution]] 2.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wiv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WIV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQD:Nemonapride'>AQD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wiu|5wiu]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wiv OCA], [http://pdbe.org/5wiv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wiv RCSB], [http://www.ebi.ac.uk/pdbsum/5wiv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wiv ProSAT]</span></td></tr> |
| - | [[Category: Huang, X | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DRD4_HUMAN DRD4_HUMAN]] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Betz, R M]] | ||
| + | [[Category: Che, T]] | ||
| + | [[Category: Dror, R O]] | ||
| + | [[Category: Huang, X P]] | ||
[[Category: Levit, A]] | [[Category: Levit, A]] | ||
| - | [[Category: | + | [[Category: McCorvy, J D]] |
| - | [[Category: | + | [[Category: Roth, B L]] |
| - | [[Category: | + | [[Category: Shoichet, B K]] |
| - | [[Category: Venkatakrishnan, A | + | [[Category: Venkatakrishnan, A J]] |
| - | + | ||
[[Category: Wacker, D]] | [[Category: Wacker, D]] | ||
| - | [[Category: Mccorvy, J.D]] | ||
[[Category: Wang, S]] | [[Category: Wang, S]] | ||
| + | [[Category: Antagonist]] | ||
| + | [[Category: Dopamine receptor]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Signaling protein-antagonist complex]] | ||
| + | [[Category: Sodium]] | ||
Revision as of 07:19, 18 October 2017
Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride
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