5wm3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of CahJ in Complex with Salicyl Adenylate== | |
| + | <StructureSection load='5wm3' size='340' side='right' caption='[[5wm3]], [[Resolution|resolution]] 1.68Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5wm3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=B5V:9-(5-O-{(S)-hydroxy[(2-hydroxybenzene-1-carbonyl)oxy]phosphoryl}-alpha-L-lyxofuranosyl)-9H-purin-6-amine'>B5V</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm3 OCA], [http://pdbe.org/5wm3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wm3 RCSB], [http://www.ebi.ac.uk/pdbsum/5wm3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cahuitamycins are biofilm inhibitors biosynthesized by a convergent NRPS pathway. Previous genetic analysis indicated that a discrete enzyme, CahJ, serves as a gatekeeper for cahuitamycin structural diversification. Herein, the CahJ protein was probed structurally, functionally and through mutasynthesis. This analysis enabled production of a new cahuitamycin congener through targeted precursor incorporation. | ||
| - | + | A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity by the Cahuitamycin Starter Unit Activating Enzyme CahJ.,Sherman DH, Tripathi A, Park SR, Sikkema A, Cho HJ, Wu J, Lee B, Xi C, Smith JL Chembiochem. 2018 May 9. doi: 10.1002/cbic.201800233. PMID:29742306<ref>PMID:29742306</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5wm3" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sikkema, A P]] | ||
| + | [[Category: Smith, J L]] | ||
| + | [[Category: Adenylation domain]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Peptide synthetase]] | ||
Revision as of 07:16, 23 May 2018
Crystal Structure of CahJ in Complex with Salicyl Adenylate
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