5wn9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of antibody 2D10 bound to the central conserved region of RSV G== | |
| - | + | <StructureSection load='5wn9' size='340' side='right' caption='[[5wn9]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wn9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WN9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wn9 OCA], [http://pdbe.org/5wn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wn9 RCSB], [http://www.ebi.ac.uk/pdbsum/5wn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wn9 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: DuBois, R M]] | ||
| + | [[Category: Fedechkin, S O]] | ||
| + | [[Category: George, N L]] | ||
| + | [[Category: Kauvar, L M]] | ||
| + | [[Category: Wolff, J T]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: G glycoprotein]] | ||
| + | [[Category: Glycoprotein]] | ||
| + | [[Category: Rsv]] | ||
| + | [[Category: Viral attachment protein]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 06:24, 14 March 2018
Structure of antibody 2D10 bound to the central conserved region of RSV G
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