5x0t

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'''Unreleased structure'''
 
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The entry 5x0t is ON HOLD until Paper Publication
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==Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8==
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<StructureSection load='5x0t' size='340' side='right' caption='[[5x0t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Lin, P., Zhang, M.-Y., Ye, S., Chen, X., Yu, X.-L., Zhang, R.-G., Zhu, P., Chen, Z.-N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x0t]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X0T FirstGlance]. <br>
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Description: Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x0t OCA], [http://pdbe.org/5x0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x0t RCSB], [http://www.ebi.ac.uk/pdbsum/5x0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x0t ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Zhang, R.-G]]
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== Function ==
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[[http://www.uniprot.org/uniprot/BASI_HUMAN BASI_HUMAN]] Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.<ref>PMID:17127621</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chen, X]]
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[[Category: Chen, Z N]]
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[[Category: Lin, P]]
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[[Category: Ye, S]]
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[[Category: Yu, X L]]
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[[Category: Zhang, M Y]]
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[[Category: Zhang, R G]]
[[Category: Zhu, P]]
[[Category: Zhu, P]]
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[[Category: Ye, S]]
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[[Category: Cd147]]
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[[Category: Lin, P]]
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[[Category: Immune system]]
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[[Category: Chen, Z.-N]]
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[[Category: Monoclonal antibody]]
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[[Category: Yu, X.-L]]
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[[Category: Chen, X]]
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[[Category: Zhang, M.-Y]]
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Revision as of 18:25, 24 January 2018

Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8

5x0t, resolution 2.50Å

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