5x74
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal Structure PDE delta in complex with compound (R, R)-1g== |
| + | <StructureSection load='5x74' size='340' side='right' caption='[[5x74]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5x74]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X74 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JAY:(2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one'>JAY</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x72|5x72]], [[5x73|5x73]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x74 OCA], [http://pdbe.org/5x74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x74 RCSB], [http://www.ebi.ac.uk/pdbsum/5x74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x74 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structural biology is a powerful tool for investigating the stereospecific interactions between a protein and its ligand. Herein, an unprecedented chiral binding pattern was observed for inhibitors of KRAS-PDEdelta interactions. Virtual screening and X-ray crystallography studies revealed that two enantiomers of a racemic inhibitor could bind at different sites. Fragment-based drug design was used to identify highly potent PDEdelta inhibitors that can be used as promising lead compounds for target validation and antitumor drug development. | ||
| - | + | Structural Biology-Inspired Discovery of Novel KRAS-PDEdelta Inhibitors.,Jiang Y, Zhuang C, Chen L, Lu J, Dong G, Miao Z, Zhang W, Li J, Sheng C J Med Chem. 2017 Oct 3. doi: 10.1021/acs.jmedchem.7b01243. PMID:28929751<ref>PMID:28929751</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5x74" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, L]] | ||
[[Category: Jiang, Y]] | [[Category: Jiang, Y]] | ||
| - | [[Category: Zhuang, C]] | ||
| - | [[Category: Wang, R]] | ||
| - | [[Category: Wang, F]] | ||
[[Category: Sheng, C]] | [[Category: Sheng, C]] | ||
| - | [[Category: | + | [[Category: Wang, F]] |
| + | [[Category: Wang, R]] | ||
| + | [[Category: Zhuang, C]] | ||
| + | [[Category: Lipid binding protein]] | ||
Revision as of 09:25, 4 October 2017
The crystal Structure PDE delta in complex with compound (R, R)-1g
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Categories: Chen, L | Jiang, Y | Sheng, C | Wang, F | Wang, R | Zhuang, C | Lipid binding protein
