This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5xof
From Proteopedia
(Difference between revisions)
m (Protected "5xof" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide I== | |
| - | + | <StructureSection load='5xof' size='340' side='right' caption='[[5xof]], [[Resolution|resolution]] 1.96Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xof]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xof OCA], [http://pdbe.org/5xof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xof RCSB], [http://www.ebi.ac.uk/pdbsum/5xof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xof ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN]] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref> [[http://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref> Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Anada, M]] | ||
| + | [[Category: Arase, H]] | ||
| + | [[Category: Furukawa, A]] | ||
| + | [[Category: Hashimoto, S]] | ||
| + | [[Category: Hatori, N]] | ||
[[Category: Ishizuka, M]] | [[Category: Ishizuka, M]] | ||
[[Category: Kakita, K]] | [[Category: Kakita, K]] | ||
| - | [[Category: | + | [[Category: Kuroki, K]] |
| - | [[Category: | + | [[Category: Maeda, N]] |
| + | [[Category: Maenaka, K]] | ||
| + | [[Category: Matsunaga, H]] | ||
| + | [[Category: Nambu, H]] | ||
[[Category: Nomura, T]] | [[Category: Nomura, T]] | ||
[[Category: Ohsaka, F]] | [[Category: Ohsaka, F]] | ||
| + | [[Category: Ose, T]] | ||
| + | [[Category: Saitoh, T]] | ||
[[Category: Sakamoto, J]] | [[Category: Sakamoto, J]] | ||
| - | [[Category: Matsunaga, H]] | ||
| - | [[Category: Maeda, N]] | ||
| - | [[Category: Saitoh, T]] | ||
| - | [[Category: Kuroki, K]] | ||
| - | [[Category: Hashimoto, S]] | ||
| - | [[Category: Nambu, H]] | ||
| - | [[Category: Maenaka, K]] | ||
[[Category: Yamada, T]] | [[Category: Yamada, T]] | ||
| - | [[Category: | + | [[Category: Glycopeptide]] |
| - | [[Category: | + | [[Category: Immune receptor]] |
| - | [[Category: | + | [[Category: Immune system]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Viral entry inhibitor]] | ||
Revision as of 07:19, 25 October 2017
Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized glycopeptide I
| |||||||||||
Categories: Anada, M | Arase, H | Furukawa, A | Hashimoto, S | Hatori, N | Ishizuka, M | Kakita, K | Kuroki, K | Maeda, N | Maenaka, K | Matsunaga, H | Nambu, H | Nomura, T | Ohsaka, F | Ose, T | Saitoh, T | Sakamoto, J | Yamada, T | Glycopeptide | Immune receptor | Immune system | Membrane protein | Viral entry inhibitor
