1lay
From Proteopedia
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| - | [[Image:1lay. | + | [[Image:1lay.jpg|left|200px]]<br /><applet load="1lay" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1lay" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1lay, resolution 2.5Å" /> | caption="1lay, resolution 2.5Å" /> | ||
'''CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE'''<br /> | '''CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LAY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cytomegalovirus Cytomegalovirus]. | + | 1LAY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cytomegalovirus Cytomegalovirus]. Known structural/functional Site: <scene name='pdbsite=CAT:Catalytic Triad'>CAT</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LAY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: viral protease]] | [[Category: viral protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:43:25 2007'' |
Revision as of 14:33, 18 December 2007
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CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE
Overview
Human herpesviruses are responsible for a variety of diseases. They are, divided into three subfamilies: alpha includes herpes simplex viruses, (HSV-1 and HSV-2) and varicella-zoster virus (VZV); beta includes, cytomegalovirus (CMV) and human herpesvirus-6 (HHV-6); and gamma includes, Epstein-Barr virus (EBV). Each virus encodes a serine protease that is, essential for its replication and is a potential target for therapeutic, intervention. Human CMV is a ubiquitous opportunistic pathogen that can, result in life-threatening infections in congenitally infected infants, immunocompromised individuals and immunosuppressed cancer or transplant, patients. Here we report the crystal structure of human CMV protease at, 2.5 angstroms resolution. The structure reveals a fold that has not been, reported for any other serine protease, and an active site consisting of a, novel catalytic triad in which the third member is a histidine instead of, an aspartic acid, or possibly a catalytic tetrad consisting of a serine, two histidines and an aspartic acid. An unusual dimer interface that is, important to the protease activity has also been identified.
About this Structure
1LAY is a Single protein structure of sequence from Cytomegalovirus. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Unique fold and active site in cytomegalovirus protease., Qiu X, Culp JS, DiLella AG, Hellmig B, Hoog SS, Janson CA, Smith WW, Abdel-Meguid SS, Nature. 1996 Sep 19;383(6597):275-9. PMID:8805707
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