1xou

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[[Image:1xou.jpg|left|200px]]
[[Image:1xou.jpg|left|200px]]
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{{Structure
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|PDB= 1xou |SIZE=350|CAPTION= <scene name='initialview01'>1xou</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1xou", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= espA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), orf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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{{STRUCTURE_1xou| PDB=1xou | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xou OCA], [http://www.ebi.ac.uk/pdbsum/1xou PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xou RCSB]</span>
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'''Crystal structure of the CesA-EspA complex'''
'''Crystal structure of the CesA-EspA complex'''
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[[Category: Strynadka, N C.J.]]
[[Category: Strynadka, N C.J.]]
[[Category: Yip, C K.]]
[[Category: Yip, C K.]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: helix bundle]]
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[[Category: Helix bundle]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:18:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:33 2008''
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Revision as of 12:18, 3 May 2008

Image:1xou.jpg

Template:STRUCTURE 1xou

Crystal structure of the CesA-EspA complex


Overview

The type III secretion system (TTSS) mediates the specific translocation of bacterial proteins into the cytoplasm of eukaryotic cells, a process essential for the virulence of many Gram-negative pathogens. The enteropathogenic Escherichia coli TTSS protein EspA forms a hollow extracellular filament believed to be a molecular conduit for type III protein translocation. Structural analysis of EspA has been hampered by its polymeric nature. We show that EspA alone is sufficient to form filamentous structures in the absence of other pathogenicity island-encoded proteins. CesA is the recently proposed chaperone of EspA, and we demonstrate that CesA traps EspA in a monomeric state and inhibits its polymerization. Crystallographic analysis of the heterodimeric CesA-EspA complex at a resolution of 2.8 A reveals that EspA contains two long a-helices, which are involved in extensive coiled-coil interactions with CesA.

About this Structure

1XOU is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural characterization of a type III secretion system filament protein in complex with its chaperone., Yip CK, Finlay BB, Strynadka NC, Nat Struct Mol Biol. 2005 Jan;12(1):75-81. Epub 2004 Dec 26. PMID:15619638 Page seeded by OCA on Sat May 3 15:18:40 2008

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