1xp5

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[[Image:1xp5.gif|left|200px]]
[[Image:1xp5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xp5 |SIZE=350|CAPTION= <scene name='initialview01'>1xp5</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1xp5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TG1:OCTANOIC+ACID+[3S-[3ALPHA,+3ABETA,+4ALPHA,+6BETA,+6ABETA,+7BETA,+8ALPHA(Z),+9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OXY]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL+ESTER'>TG1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1xp5| PDB=1xp5 | SCENE= }}
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|RELATEDENTRY=[[1t5t|1T5T]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp5 OCA], [http://www.ebi.ac.uk/pdbsum/1xp5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xp5 RCSB]</span>
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}}
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'''Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form'''
'''Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form'''
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[[Category: Olesen, C.]]
[[Category: Olesen, C.]]
[[Category: Sorensen, T L.S.]]
[[Category: Sorensen, T L.S.]]
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[[Category: aluminium fluoride]]
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[[Category: Aluminium fluoride]]
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[[Category: ca2+-atpase]]
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[[Category: Ca2+-atpase]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:19:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:40 2008''
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Revision as of 12:19, 3 May 2008

Image:1xp5.gif

Template:STRUCTURE 1xp5

Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form


Overview

P-type ATPases extract energy by hydrolysis of adenosine triphosphate (ATP) in two steps, formation and breakdown of a covalent phosphoenzyme intermediate. This process drives active transport and countertransport of the cation pumps. We have determined the crystal structure of rabbit sarcoplasmic reticulum Ca2+ adenosine triphosphatase in complex with aluminum fluoride, which mimics the transition state of hydrolysis of the counterion-bound (protonated) phosphoenzyme. On the basis of structural analysis and biochemical data, we find this form to represent an occluded state of the proton counterions. Hydrolysis is catalyzed by the conserved Thr-Gly-Glu-Ser motif, and it exploits an associative nucleophilic reaction mechanism of the same type as phosphoryl transfer from ATP. On this basis, we propose a general mechanism of occluded transition states of Ca2+ transport and H+ countertransport coupled to phosphorylation and dephosphorylation, respectively.

About this Structure

1XP5 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Dephosphorylation of the calcium pump coupled to counterion occlusion., Olesen C, Sorensen TL, Nielsen RC, Moller JV, Nissen P, Science. 2004 Dec 24;306(5705):2251-5. PMID:15618517 Page seeded by OCA on Sat May 3 15:19:22 2008

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