5xxi

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m (Protected "5xxi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5xxi is ON HOLD until Paper Publication
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==Crystal structure of CYP2C9 in complex with multiple losartan molecules==
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<StructureSection load='5xxi' size='340' side='right' caption='[[5xxi]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xxi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXI FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSN:[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol'>LSN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxi OCA], [http://pdbe.org/5xxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxi RCSB], [http://www.ebi.ac.uk/pdbsum/5xxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
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__TOC__
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</StructureSection>
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[[Category: Adachi, M]]
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[[Category: Maekawa, K]]
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[[Category: Shah, M B]]
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[[Category: Cyp2c9]]
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[[Category: Oxidoreductase]]
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[[Category: P450 2c9]]

Revision as of 07:19, 25 October 2017

Crystal structure of CYP2C9 in complex with multiple losartan molecules

5xxi, resolution 2.30Å

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