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1xpa

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[[Image:1xpa.jpg|left|200px]]
[[Image:1xpa.jpg|left|200px]]
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{{Structure
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|PDB= 1xpa |SIZE=350|CAPTION= <scene name='initialview01'>1xpa</scene>
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The line below this paragraph, containing "STRUCTURE_1xpa", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=NUL:Zn+Binding+Site'>NUL</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1xpa| PDB=1xpa | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpa OCA], [http://www.ebi.ac.uk/pdbsum/1xpa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xpa RCSB]</span>
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}}
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'''SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE'''
'''SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE'''
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[[Category: Shirakawa, M.]]
[[Category: Shirakawa, M.]]
[[Category: Tanaka, K.]]
[[Category: Tanaka, K.]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: nucleotide excision repair]]
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[[Category: Nucleotide excision repair]]
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[[Category: zinc-finger]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:19:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:44 2008''
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Revision as of 12:19, 3 May 2008

Image:1xpa.jpg

Template:STRUCTURE 1xpa

SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE


Overview

The solution structure of the central domain of the human nucleotide excision repair protein XPA, which binds to damaged DNA and replication protein A (RPA), was determined by nuclear magnetic resonance (NMR) spectroscopy. The central domain consists of a zinc-containing subdomain and a C-terminal subdomain. The zinc-containing subdomain has a compact globular structure and is distinct from the zinc-fingers found in transcription factors. The C-terminal subdomain folds into a novel alpha/beta structure with a positively charged superficial cleft. From the NMR spectra of the complexes, DNA and RPA binding surfaces are suggested.

About this Structure

1XPA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA., Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M, Nat Struct Biol. 1998 Aug;5(8):701-6. PMID:9699634 Page seeded by OCA on Sat May 3 15:19:42 2008

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