1ldp
From Proteopedia
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| - | [[Image:1ldp. | + | [[Image:1ldp.jpg|left|200px]]<br /><applet load="1ldp" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ldp" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1ldp, resolution 3.1Å" /> | caption="1ldp, resolution 3.1Å" /> | ||
'''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''<br /> | '''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LDP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NDG as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 1LDP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NDG as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=CNP:This Nine Amino Acid Model Best Fits The Electron Densit ...'>CNP</scene> and <scene name='pdbsite=CNQ:This Nine Residue Model Of Antigenic Peptide Ql9 Also Fi ...'>CNQ</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LDP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: peptide antigen]] | [[Category: peptide antigen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:43:40 2007'' |
Revision as of 14:33, 18 December 2007
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CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES
Overview
MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity, alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a, mixture of bound peptides at 3.1 A to construct a model of the allogeneic, 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure., A prominent ridge on the floor of the Ld peptide-binding groove, not, present in Kb, creates a C-terminal bulge in Ld peptides that greatly, increases interactions with the 2C beta-chain. Furthermore, weak, electrostatic complementarity between Asp77 on the alpha1 helix of Kb and, 2C is enhanced in the allogeneic complex by closer proximity of QL9, peptide residue AspP8 to the 2C HV4 loop.
About this Structure
1LDP is a Protein complex structure of sequences from Drosophila melanogaster and Mus musculus with NDG as ligand. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes., Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 May;8(5):553-62. PMID:9620676
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