5y7g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of nuclease== | |
| - | + | <StructureSection load='5y7g' size='340' side='right' caption='[[5y7g]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5y7g]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphodiesterase_I Phosphodiesterase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.1 3.1.4.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7g OCA], [http://pdbe.org/5y7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7g RCSB], [http://www.ebi.ac.uk/pdbsum/5y7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FAN1_PSEAE FAN1_PSEAE]] Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828).[UniProtKB:Q9Y2M0]<ref>PMID:24981866</ref> <ref>PMID:25319828</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phosphodiesterase I]] | ||
| + | [[Category: Cho, Y]] | ||
[[Category: Jin, H]] | [[Category: Jin, H]] | ||
| - | [[Category: | + | [[Category: Hydrolase-dna complex]] |
| + | [[Category: Nuclease]] | ||
Revision as of 06:26, 14 March 2018
Crystal structure of nuclease
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