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1xsn

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[[Image:1xsn.gif|left|200px]]
[[Image:1xsn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xsn |SIZE=350|CAPTION= <scene name='initialview01'>1xsn</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1xsn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2DT:3&#39;-DEOXYTHYMIDINE-5&#39;-MONOPHOSPHATE'>2DT</scene>, <scene name='pdbligand=D3T:2&#39;,3&#39;-DIDEOXY-THYMIDINE-5&#39;-TRIPHOSPHATE'>D3T</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= POLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1xsn| PDB=1xsn | SCENE= }}
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|RELATEDENTRY=[[1xsl|1XSL]], [[1xsp|1XSP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsn OCA], [http://www.ebi.ac.uk/pdbsum/1xsn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xsn RCSB]</span>
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}}
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'''Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP'''
'''Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP'''
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[[Category: Kunkel, T A.]]
[[Category: Kunkel, T A.]]
[[Category: Pedersen, L C.]]
[[Category: Pedersen, L C.]]
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[[Category: dna polymerase lambda]]
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[[Category: Dna polymerase lambda]]
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[[Category: helix-hairpin-helix]]
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[[Category: Helix-hairpin-helix]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:27:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:08 2008''
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Revision as of 12:27, 3 May 2008

Image:1xsn.gif

Template:STRUCTURE 1xsn

Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP


Overview

Pol lambda is a family X member believed to fill short gaps during DNA repair. Here we report crystal structures of Pol lambda representing three steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol lambda does not undergo large subdomain movements during catalysis, and they provide a clear characterization of the geometry and stereochemistry of the in-line nucleotidyl transfer reaction.

About this Structure

1XSN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A closed conformation for the Pol lambda catalytic cycle., Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC, Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19. PMID:15608652 Page seeded by OCA on Sat May 3 15:27:44 2008

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