1xt8

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[[Image:1xt8.gif|left|200px]]
[[Image:1xt8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1xt8 |SIZE=350|CAPTION= <scene name='initialview01'>1xt8</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1xt8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Cj0982c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197 Campylobacter jejuni])
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-->
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|DOMAIN=
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{{STRUCTURE_1xt8| PDB=1xt8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt8 OCA], [http://www.ebi.ac.uk/pdbsum/1xt8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xt8 RCSB]</span>
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}}
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'''Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution'''
'''Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution'''
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[[Category: Wilkinson, A J.]]
[[Category: Wilkinson, A J.]]
[[Category: Wilson, K S.]]
[[Category: Wilson, K S.]]
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[[Category: abc transport]]
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[[Category: Abc transport]]
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[[Category: amino-acid transporter periplasmic solute-binding protein]]
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[[Category: Amino-acid transporter periplasmic solute-binding protein]]
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[[Category: campylobacter jejuni]]
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[[Category: Campylobacter jejuni]]
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[[Category: cysteine uptake]]
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[[Category: Cysteine uptake]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:14:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:19 2008''
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Revision as of 05:14, 13 April 2008

Image:1xt8.gif

Template:STRUCTURE 1xt8

Crystal Structure of Cysteine-Binding Protein from Campylobacter jejuni at 2.0 A Resolution


Overview

Campylobacter jejuni is a Gram-negative food-borne pathogen associated with gastroenteritis in humans as well as cases of the autoimmune disease Guillain-Barre syndrome. C. jejuni is asaccharolytic because it lacks an active glycolytic pathway for the use of sugars as a carbon source. This suggests an increased reliance on amino acids as nutrients and indeed the genome sequence of this organism indicates the presence of a number of amino acid uptake systems. Cj0982, also known as CjaA, is a putative extracytoplasmic solute receptor for one such uptake system as well as a major surface antigen and vaccine candidate. The crystal structure of Cj0982 reveals a two-domain protein with density in the enclosed cavity between the domains that clearly defines the presence of a bound cysteine ligand. Fluorescence titration experiments were used to demonstrate that Cj0982 binds cysteine tightly and specifically with a K(d) of approximately 10(-7) M consistent with a role as a receptor for a high-affinity transporter. These data imply that Cj0982 is the binding protein component of an ABC-type cysteine transporter system and that cysteine uptake is important in the physiology of C. jejuni.

About this Structure

1XT8 is a Single protein structure of sequence from Campylobacter jejuni. Full crystallographic information is available from OCA.

Reference

An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein., Muller A, Thomas GH, Horler R, Brannigan JA, Blagova E, Levdikov VM, Fogg MJ, Wilson KS, Wilkinson AJ, Mol Microbiol. 2005 Jul;57(1):143-55. PMID:15948956 Page seeded by OCA on Sun Apr 13 08:14:33 2008

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