1xt9

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[[Image:1xt9.gif|left|200px]]
[[Image:1xt9.gif|left|200px]]
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{{Structure
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|GENE= SENP8, FKSG8, PRSC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NEDD8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1xt9| PDB=1xt9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt9 OCA], [http://www.ebi.ac.uk/pdbsum/1xt9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xt9 RCSB]</span>
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'''Crystal Structure of Den1 in complex with Nedd8'''
'''Crystal Structure of Den1 in complex with Nedd8'''
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[[Category: Wilkinson, K D.]]
[[Category: Wilkinson, K D.]]
[[Category: Wu, K.]]
[[Category: Wu, K.]]
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[[Category: cysteine protease]]
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[[Category: Cysteine protease]]
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[[Category: ubiquitin-like]]
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[[Category: Ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:29:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:20 2008''
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Revision as of 12:29, 3 May 2008

Image:1xt9.gif

Template:STRUCTURE 1xt9

Crystal Structure of Den1 in complex with Nedd8


Overview

The Nedd8 conjugation pathway is conserved from yeast to humans and is essential in many organisms. Nedd8 is conjugated to cullin proteins in a process that alters SCF E3 ubiquitin ligase activity, and it is presumed that Nedd8 deconjugation would reverse these effects. We now report the X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis. Although Den1 is closely related to the SUMO-specific protease family (Ulp/Senp family), structural analysis of the interface suggests determinants involved in Nedd8 selectivity by Den1 over other ubiquitin-like family members and suggests how the Ulp/Senp architecture has been modified to interact with different ubiquitin-like modifiers.

About this Structure

1XT9 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1., Reverter D, Wu K, Erdene TG, Pan ZQ, Wilkinson KD, Lima CD, J Mol Biol. 2005 Jan 7;345(1):141-51. PMID:15567417 Page seeded by OCA on Sat May 3 15:29:03 2008

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