5yew
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion== | |
- | + | <StructureSection load='5yew' size='340' side='right' caption='[[5yew]], [[Resolution|resolution]] 3.20Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5yew]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YEW FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
- | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yew OCA], [http://pdbe.org/5yew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yew RCSB], [http://www.ebi.ac.uk/pdbsum/5yew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yew ProSAT]</span></td></tr> |
- | [[Category: | + | </table> |
- | [[Category: | + | == Function == |
- | [[Category: | + | [[http://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN]] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref> |
- | [[Category: | + | == References == |
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Huang, X]] | ||
+ | [[Category: Qi, Y]] | ||
+ | [[Category: Yan, L]] | ||
+ | [[Category: Yu, C]] | ||
+ | [[Category: Fusion]] | ||
+ | [[Category: Hydrolase]] | ||
+ | [[Category: Mfn1]] | ||
+ | [[Category: Mitochondria]] |
Revision as of 05:54, 31 January 2018
Structural basis for GTP hydrolysis and conformational change of mitofusin 1 in mediating mitochondrial fusion
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Categories: Huang, X | Qi, Y | Yan, L | Yu, C | Fusion | Hydrolase | Mfn1 | Mitochondria