6aqb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the SH3 domain of MLK3 bound to peptide generated from phage display== | |
| - | + | <StructureSection load='6aqb' size='340' side='right' caption='[[6aqb]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6aqb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AQB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr> |
| - | [[Category: Kall, S | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aqb OCA], [http://pdbe.org/6aqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aqb RCSB], [http://www.ebi.ac.uk/pdbsum/6aqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aqb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/M3K11_HUMAN M3K11_HUMAN]] Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.<ref>PMID:12529434</ref> <ref>PMID:15258589</ref> <ref>PMID:8195146</ref> <ref>PMID:9003778</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mitogen-activated protein kinase kinase kinase]] | ||
| + | [[Category: Kall, S K]] | ||
[[Category: Lavie, A]] | [[Category: Lavie, A]] | ||
| + | [[Category: Mlk3]] | ||
| + | [[Category: Phage display]] | ||
| + | [[Category: Sh3]] | ||
| + | [[Category: Signalling protein]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:10, 4 July 2018
Structure of the SH3 domain of MLK3 bound to peptide generated from phage display
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