1xwv

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[[Image:1xwv.gif|left|200px]]
[[Image:1xwv.gif|left|200px]]
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{{Structure
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|PDB= 1xwv |SIZE=350|CAPTION= <scene name='initialview01'>1xwv</scene>, resolution 1.83&Aring;
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The line below this paragraph, containing "STRUCTURE_1xwv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1xwv| PDB=1xwv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwv OCA], [http://www.ebi.ac.uk/pdbsum/1xwv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xwv RCSB]</span>
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}}
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'''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity'''
'''Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity'''
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[[Category: Skov, L K.]]
[[Category: Skov, L K.]]
[[Category: Spangfort, M.]]
[[Category: Spangfort, M.]]
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[[Category: beta sheet]]
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[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:36:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:55:47 2008''
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Revision as of 12:36, 3 May 2008

Image:1xwv.gif

Template:STRUCTURE 1xwv

Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity


Overview

The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.

About this Structure

1XWV is a Single protein structure of sequence from Dermatophagoides farinae. Full crystallographic information is available from OCA.

Reference

Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity., Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M, FEBS Lett. 2005 Feb 14;579(5):1208-12. Epub 2005 Jan 21. PMID:15710415 Page seeded by OCA on Sat May 3 15:36:31 2008

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