Rho guanine nucleotide exchange factor

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Line 22: Line 22:
**[[3p6a]] – hGEF DH/PH domain (mutant)<br />
**[[3p6a]] – hGEF DH/PH domain (mutant)<br />
**[[1shz]], [[3ab3]] – hGEF N terminal + guanine nucleotide-binding protein<br />
**[[1shz]], [[3ab3]] – hGEF N terminal + guanine nucleotide-binding protein<br />
 +
 +
*Rho guanine nucleotide exchange factor 2
 +
 +
**[[5efx]] - hGEF residues 439-582<br />
*Rho guanine nucleotide exchange factor 4 (Asef)
*Rho guanine nucleotide exchange factor 4 (Asef)
Line 46: Line 50:
**[[2df6]] – hGEF SH3 domain + PAK-1 peptide <br />
**[[2df6]] – hGEF SH3 domain + PAK-1 peptide <br />
**[[1zsg]] – hGEF residues 179-243 + PAK-1 peptide – NMR<br />
**[[1zsg]] – hGEF residues 179-243 + PAK-1 peptide – NMR<br />
 +
**[[5sxp]] - hGEF residues 183-243 + E3 ubiquitin-protein ligase itchy<br />
**[[2p4r]] – rGEF SH3 domain + E3 ubiquitin protein ligase peptide <br />
**[[2p4r]] – rGEF SH3 domain + E3 ubiquitin protein ligase peptide <br />
**[[3l4f]] – rGEF coiled-coil domain + SHANK1 PDZ domain <br />
**[[3l4f]] – rGEF coiled-coil domain + SHANK1 PDZ domain <br />
Line 66: Line 71:
**[[2dls]] – hGEF PDZ domain - NMR<br />
**[[2dls]] – hGEF PDZ domain - NMR<br />
-
**[[3kz1]], [[3t06]] – hGEF DH/PH domain + transforming protein RhoA <br />
+
**[[5tyt]] - hGEF PDZ domain/CXCR2 peptide<br />
 +
**[[3kz1]], [[3t06]], [[5jhg]], [[5jhh]] – hGEF DH/PH domain + transforming protein RhoA <br />
**[[1xcg]] – hGEF DH/PH domain + transforming protein RhoA - NMR<br />
**[[1xcg]] – hGEF DH/PH domain + transforming protein RhoA - NMR<br />
**[[3cx6]] – rGEF RGS domain + guanine nucleotide-binding protein <br />
**[[3cx6]] – rGEF RGS domain + guanine nucleotide-binding protein <br />
 +
**[[5e6p]] - mGEF PDZ domain + plexin-B2<br />
*Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
*Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)

Revision as of 17:36, 27 September 2017

Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code 3kz1)

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3D Structures of Rho guanine nucleotide exchange factor

Updated on 27-September-2017

References

  1. ↑ Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. PMID:23303910 doi:http://dx.doi.org/10.1152/physrev.00003.2012
  2. ↑ Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep, 16. PMID:24037532 doi:http://dx.doi.org/10.1038/onc.2013.362

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Michal Harel, Joel L. Sussman

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