Ribosomal protein S6 kinase
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry [[2z7s]])' scene='43/434545/Cv/2'> |
== Function == | == Function == | ||
[[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program. | [[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program. | ||
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**[[4el9]] - mRPS6K α−3 N-terminal kinase domain + inhibitor<br /> | **[[4el9]] - mRPS6K α−3 N-terminal kinase domain + inhibitor<br /> | ||
**[[4nus]], [[4nw5]], [[4nw6]] - hRPS6K α−3 N-terminal kinase domain + inhibitor<br /> | **[[4nus]], [[4nw5]], [[4nw6]] - hRPS6K α−3 N-terminal kinase domain + inhibitor<br /> | ||
| - | **[[4d9t]], [[4d9u]], [[4jg6]], [[4jg7]], [[4jg8]] - hRPS6K α−3 C-terminal kinase domain + inhibitor<br /> | + | **[[4d9t]], [[4d9u]], [[4jg6]], [[4jg7]], [[4jg8]], [[5o1s]] - hRPS6K α−3 C-terminal kinase domain + inhibitor<br /> |
**[[4m8t]], [[4mao]] - mRPS6K α−3 C-terminal kinase domain (mutant) + inhibitor<br /> | **[[4m8t]], [[4mao]] - mRPS6K α−3 C-terminal kinase domain (mutant) + inhibitor<br /> | ||
**[[3kn5]] - hRPS6K α−5 C-terminal kinase domain+AMPPNP<br /> | **[[3kn5]] - hRPS6K α−5 C-terminal kinase domain+AMPPNP<br /> | ||
Revision as of 22:41, 13 September 2018
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3D Structures of Ribosomal protein S6 kinase
Updated on 13-September-2018
References
- ↑ Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012 Jan 1;441(1):1-21. doi: 10.1042/BJ20110892. PMID:22168436 doi:http://dx.doi.org/10.1042/BJ20110892
- ↑ Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors. 2009 Feb;27(1):12-21. doi: 10.1080/08977190802556986. PMID:19085255 doi:http://dx.doi.org/10.1080/08977190802556986
- ↑ Couty S, Westwood IM, Kalusa A, Cano C, Travers J, Boxall K, Chow CL, Burns S, Schmitt J, Pickard L, Barillari C, McAndrew PC, Clarke PA, Linardopoulos S, Griffin RJ, Aherne GW, Raynaud FI, Workman P, Jones K, van Montfort RL. The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget. 2013 Aug 25. PMID:24072592
- ↑ Ikuta M, Kornienko M, Byrne N, Reid JC, Mizuarai S, Kotani H, Munshi SK. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Protein Sci. 2007 Dec;16(12):2626-35. Epub 2007 Oct 26. PMID:17965187 doi:http://dx.doi.org/10.1110/ps.073123707
