5n6c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate== | |
| - | + | <StructureSection load='5n6c' size='340' side='right' caption='[[5n6c]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5n6c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6c OCA], [http://pdbe.org/5n6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6c RCSB], [http://www.ebi.ac.uk/pdbsum/5n6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6c ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phosphoglycerate dehydrogenase]] | ||
[[Category: Basle, A]] | [[Category: Basle, A]] | ||
| + | [[Category: Cano, C]] | ||
| + | [[Category: Curtin, N J]] | ||
| + | [[Category: Noble, M E.M]] | ||
[[Category: Tucker, J]] | [[Category: Tucker, J]] | ||
| - | [[Category: | + | [[Category: Unterlass, J E]] |
| + | [[Category: Dehydrogenase]] | ||
| + | [[Category: Enzymology]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Serine metabolism]] | ||
Revision as of 07:37, 22 November 2017
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate
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