5y7n

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'''Unreleased structure'''
 
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The entry 5y7n is ON HOLD until Paper Publication
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==Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol==
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<StructureSection load='5y7n' size='340' side='right' caption='[[5y7n]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Hong, Z., Liping, Z., Cuiyun, L., Wei, Z.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5y7n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7N FirstGlance]. <br>
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Description: Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8QL:(3S,6S,8S,9S,10R,13S,14R)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol'>8QL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7n OCA], [http://pdbe.org/5y7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7n RCSB], [http://www.ebi.ac.uk/pdbsum/5y7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7n ProSAT]</span></td></tr>
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[[Category: Wei, Z]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Cuiyun, L]]
[[Category: Cuiyun, L]]
[[Category: Hong, Z]]
[[Category: Hong, Z]]
[[Category: Liping, Z]]
[[Category: Liping, Z]]
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[[Category: Wei, Z]]
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[[Category: Akr1b10]]
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[[Category: Antitumor protein]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Oxidoreductase]]
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[[Category: Steroid]]

Revision as of 07:18, 29 August 2018

Crystal structure of AKR1B10 in complex with NADP+ and Androst-4-ene-3-beta-6-alpha-diol

5y7n, resolution 2.50Å

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