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Single-stranded DNA-binding protein

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<StructureSection load='1eqq' size='450' side='right' scene='' caption='E. coli SSB complex with ssDNA and UMP [[1eqq]]'>
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<StructureSection load='1eqq' size='450' side='right' scene='' caption='E. coli SSB complex with ssDNA (stick model) and UMP [[1eqq]]'>
'''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities<ref>PMID:22976174</ref>.<br />
'''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities<ref>PMID:22976174</ref>.<br />
* '''Viral SSB proteins''' are monomeric.<br />
* '''Viral SSB proteins''' are monomeric.<br />

Revision as of 08:05, 26 October 2017


E. coli SSB complex with ssDNA (stick model) and UMP 1eqq

Drag the structure with the mouse to rotate

3D Structures of single-stranded DNA-binding protein

Updated on 26-October-2017

References

  1. ↑ Marceau AH. Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repair. Methods Mol Biol. 2012;922:1-21. doi: 10.1007/978-1-62703-032-8_1. PMID:22976174 doi:http://dx.doi.org/10.1007/978-1-62703-032-8_1

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Michal Harel, Alexander Berchansky

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