Spectrin

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* Spectrin α
* Spectrin α
 +
**[[2kr3]], [[4f17]], [[4f16]] - cSPTA SH3 domain<br />
 +
**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPTA SH3 domain (mutant)<br />
**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
**[[2lj3]] - cSPTA SH3 domain – NMR<br />
**[[2lj3]] - cSPTA SH3 domain – NMR<br />
-
**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]] - cSPTA SH3 domain (mutant)<br />
 
**[[1u4q]] – cSPTA repeats 15-17 <br />
**[[1u4q]] – cSPTA repeats 15-17 <br />
**[[1u5p]] - cSPTA repeats 15-16<br />
**[[1u5p]] - cSPTA repeats 15-16<br />
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**[[1aj3]] - cSPTA repeat 16 - NMR<br />
**[[1aj3]] - cSPTA repeat 16 - NMR<br />
**[[1owa]] - hSPTA tetramerization domain – NMR<br />
**[[1owa]] - hSPTA tetramerization domain – NMR<br />
-
**[[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] – cSPTA SH3 domain (mutant)<br />
+
**[[5j4o]] - hSPTA repeats 16-17<br />
-
**[[2kr3]], [[4f17]], [[4f16]] - cSPTA SH3 domain<br />
+
* Spectrin β1
* Spectrin β1

Revision as of 17:14, 5 October 2017

Human spectrin α (grey) and β1 chain (green) 3lbx

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3D Structures of Spectrin

Updated on 05-October-2017

References

  1. Das A, Base C, Dhulipala S, Dubreuil RR. Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway. J Cell Biol. 2006 Oct 23;175(2):325-35. PMID:17060500 doi:http://dx.doi.org/10.1083/jcb.200602095
  2. Coetzer T, Palek J, Lawler J, Liu SC, Jarolim P, Lahav M, Prchal JT, Wang W, Alter BP, Schewitz G, et al.. Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis. Blood. 1990 Jun 1;75(11):2235-44. PMID:2346784
  3. Dhermy D, Galand C, Bournier O, Cynober T, Mechinaud F, Tchemia G, Garbarz M. Hereditary spherocytosis with spectrin deficiency related to null mutations of the beta-spectrin gene. Blood Cells Mol Dis. 1998 Jun;24(2):251-61. PMID:9714702 doi:http://dx.doi.org/10.1006/bcmd.1998.0190

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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