1yaa

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[[Image:1yaa.gif|left|200px]]
[[Image:1yaa.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1yaa |SIZE=350|CAPTION= <scene name='initialview01'>1yaa</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1yaa", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MAE:MALEIC+ACID'>MAE</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1yaa| PDB=1yaa | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yaa OCA], [http://www.ebi.ac.uk/pdbsum/1yaa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yaa RCSB]</span>
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}}
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'''ASPARTATE AMINOTRANSFERASE FROM SACCHAROMYCES CEREVISIAE CYTOPLASM'''
'''ASPARTATE AMINOTRANSFERASE FROM SACCHAROMYCES CEREVISIAE CYTOPLASM'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Jeffery, C J.]]
[[Category: Jeffery, C J.]]
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[[Category: aminotransferase]]
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[[Category: Aminotransferase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:04:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:00:50 2008''
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Revision as of 13:04, 3 May 2008

Image:1yaa.gif

Template:STRUCTURE 1yaa

ASPARTATE AMINOTRANSFERASE FROM SACCHAROMYCES CEREVISIAE CYTOPLASM


Overview

The crystal structure of Saccharomyces cerevisiae cytoplasmic aspartate aminotransferase (EC 2.6.1.1) has been determined to 2.05 A resolution in the presence of the cofactor pyridoxal-5'-phosphate and the competitive inhibitor maleate. The structure was solved by the method of molecular replacement. The final value of the crystallographic R-factor after refinement was 23.1% with good geometry of the final model. The yeast cytoplasmic enzyme is a homodimer with two identical active sites containing residues from each subunit. It is found in the "closed" conformation with a bound maleate inhibitor in each active site. It shares the same three-dimensional fold and active site residues as the aspartate aminotransferases from Escherichia coli, chicken cytoplasm, and chicken mitochondria, although it shares less than 50% sequence identity with any of them. The availability of four similar enzyme structures from distant regions of the evolutionary tree provides a measure of tolerated changes that can arise during millions of years of evolution.

About this Structure

1YAA is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase., Jeffery CJ, Barry T, Doonan S, Petsko GA, Ringe D, Protein Sci. 1998 Jun;7(6):1380-7. PMID:9655342 Page seeded by OCA on Sat May 3 16:04:05 2008

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OCA

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