TATA-Binding Protein
From Proteopedia
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| - | <StructureSection load='1tgh' size=' | + | <StructureSection load='1tgh' size='350' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'> |
== Function == | == Function == | ||
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>. Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also<br /> | [[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>. Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also<br /> | ||
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* TBP in RNA polymerase II complex | * TBP in RNA polymerase II complex | ||
| - | **[[5fyw]], [[5fz5]], [[5fmf]], [[4v1n]], [[4v1o]] – yTBP + DNA-directed RNA polymerase II + TFII + DNA<br /> | + | **[[5fyw]], [[5fz5]], [[5fmf]], [[4v1n]], [[4v1o]], [[5sva]], [[5oqj]], [[5oqm]] – yTBP + DNA-directed RNA polymerase II + TFII + DNA - Cryo EM<br /> |
| - | **[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTBP + DNA-directed RNA polymerase II + TFII + DNA<br /> | + | **[[5iy6]], [[5iy7]], [[5iy8]], [[5iy9]], [[5iya]], [[5iyb]], [[5iyc]], [[5iyd]] – hTBP + DNA-directed RNA polymerase II + TFII + DNA - Cryo EM<br /> |
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Revision as of 18:23, 24 September 2018
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3D Structures of TATA-binding protein
Updated on 24-September-2018
References
- ↑ Caporaso N. Genetic susceptibility in the occupational setting: introduction to the workshop. Med Lav. 1995 May-Jun;86(3):199-206. PMID:7565278
- ↑ van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72. PMID:15916858 doi:http://dx.doi.org/10.1016/j.neuroscience.2005.03.024
- ↑ Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE. How proteins recognize the TATA box. J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 doi:10.1006/jmbi.1996.0456
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