This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Telethonin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
 
+
<StructureSection load='1ya5' size='350' side='right' scene='Telethonin/Cv/1' caption='Crystal structure of telethonin (dark green) in complex with titin domains z1z2 dimer (grey and light green) and sulfate (PDB code [[1ya5]])'>
-
<StructureSection load='1ya5' size='450' side='right' scene='Telethonin/Cv/1' caption='Crystal structure of telethonin (dark green) in complex with titin domains z1z2 dimer (grey and light green) and sulfate (PDB code [[1ya5]])'>
+
== Function ==
== Function ==
[[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly<ref>PMID:11699871</ref>. It is called [[titin]] cap protein. See also [[Group:MUZIC:Telethonin]].
[[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly<ref>PMID:11699871</ref>. It is called [[titin]] cap protein. See also [[Group:MUZIC:Telethonin]].

Revision as of 19:44, 6 October 2017

Crystal structure of telethonin (dark green) in complex with titin domains z1z2 dimer (grey and light green) and sulfate (PDB code 1ya5)

Drag the structure with the mouse to rotate

3D Structures of Telethonin

2f8v, 1ya5 - telethonin+ hTTN residues 1-196 - human

References

  1. ↑ Faulkner G, Lanfranchi G, Valle G. Telethonin and other new proteins of the Z-disc of skeletal muscle. IUBMB Life. 2001 May;51(5):275-82. PMID:11699871 doi:10.1080/152165401317190761
  2. ↑ Knoll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schafer K, Knoll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didie M, Quentin T, Maier LS, Teucher N, Unsold B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub, 2011 Jul 28. PMID:21799151 doi:http://dx.doi.org/10.1161/CIRCRESAHA.111.245787

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Telethonin"
Personal tools