1ybi
From Proteopedia
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'''Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A''' | '''Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A''' | ||
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[[Category: Schwarzenbacher, R.]] | [[Category: Schwarzenbacher, R.]] | ||
[[Category: Stevens, R C.]] | [[Category: Stevens, R C.]] | ||
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Revision as of 13:06, 3 May 2008
Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A
Overview
The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold.
About this Structure
1YBI is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
Reference
The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex., Arndt JW, Gu J, Jaroszewski L, Schwarzenbacher R, Hanson MA, Lebeda FJ, Stevens RC, J Mol Biol. 2005 Mar 4;346(4):1083-93. Epub 2005 Jan 20. PMID:15701519 Page seeded by OCA on Sat May 3 16:06:55 2008
