Kinesin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 32: Line 32:
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
 +
**[[4ejq]], [[4egx]] - hKIF1A FHA domain - human<br />
**[[3wrd]] – mKIF5C<br />
**[[3wrd]] – mKIF5C<br />
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br />
**[[2g1l]] - hKIF1C FHA domain<br />
**[[2g1l]] - hKIF1C FHA domain<br />
 +
**[[5wdh]] – hKIF1C MD<br />
**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
**[[2owm]] – NcKIF1C MD – ''Neurospora crassa''<br />
**[[1goj]] – NcKIF MD<br />
**[[1goj]] – NcKIF MD<br />
Line 41: Line 43:
**[[5wdh]] – hKIFC1 MD<br />
**[[5wdh]] – hKIFC1 MD<br />
**[[2eh0]] - hKIF1B FHA domain – NMR<br />
**[[2eh0]] - hKIF1B FHA domain – NMR<br />
 +
**[[5d3a]] – hKIF21A coiled coil domain residues 938-1017 <br />
**[[2edu]] – hKIF22 C-terminal – NMR<br />
**[[2edu]] – hKIF22 C-terminal – NMR<br />
 +
**[[4a14]] – hKIF7 MD <br />
 +
**[[2xt3]] – hKIF7 MD (mutant)<br />
 +
**[[4bn2]] – hKIF15 MD<br />
**[[2v14]] – hKIF16B<br />
**[[2v14]] – hKIF16B<br />
-
**[[2heh]] – hKIF2C<br />
+
**[[2heh]], [[4ubf]], [[5y05]] – hKIF2C<br />
 +
**[[3j2u]] – hKIF10A head domain – Cryo EM<br />
 +
**[[5djo]] – mKIF13A CC1-FHA domain <br />
 +
**[[5djn]] – mKIF13A coiled-coil domain (mutant)<br />
**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
**[[2cow]] – hKIF13B CAP-gly domain – NMR<br />
**[[1bg2]] – hKIF MD<br />
**[[1bg2]] – hKIF MD<br />
-
**[[5lt3]], [[5lt4]] – hKIF MD (mutant) <br />
+
**[[5lt3]], [[5lt4]], [[5lt2]], [[5lt0]], [[5lt1]] – hKIF MD (mutant) <br />
**[[3kin]], [[2kin]] – rKIF MD - rat<br />
**[[3kin]], [[2kin]] – rKIF MD - rat<br />
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br />
Line 58: Line 67:
**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
**[[1vfx]] - mKIF1A MD+ADP-Mg-AlFx<br />
**[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
**[[1vfz]] - mKIF1A MD+ADP-Mg-VO4<br />
-
**[[1v8j]] – mKIF2C MD+Mg-ADP<br />
+
**[[1v8j]], [[5xja]], [[5xjb]] – mKIF2C MD+Mg-ADP<br />
**[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
**[[1i5s]] - mKIF2C MD (mutant)+Mg-ADP<br />
**[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
**[[1i6i]] - mKIF2C MD (mutant)+Mg-AMPPCP<br />
Line 64: Line 73:
**[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br />
**[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br />
**[[3x2t]] – mKIF5C + ADP<br />
**[[3x2t]] – mKIF5C + ADP<br />
 +
**[[5gsy]] – mKIF19A MD + GDP<br />
 +
**[[5gsz]] – mKIF19A MD + ADP<br />
**[[2cjo]] – hKIF13+inhibitor 30<br />
**[[2cjo]] – hKIF13+inhibitor 30<br />
**[[3nwn]] – hKIF9+ADP<br />
**[[3nwn]] – hKIF9+ADP<br />
-
**[[5wde]] – hKIFC3+ADP<br />
+
**[[5wde]], [[2h58]] – hKIFC3+ADP<br />
**[[2gry]] – hKIF2+ADP<br />
**[[2gry]] – hKIF2+ADP<br />
**[[3uyq]] – pKIF1A head+AMPPNP – pig<br />
**[[3uyq]] – pKIF1A head+AMPPNP – pig<br />
**[[2hxh]] - pKIF1A head+ADP<br />
**[[2hxh]] - pKIF1A head+ADP<br />
 +
**[[2hxf]] - pKIF1A head+AMPPNP<br />
*''Kinesin heavy chain complex with protein''
*''Kinesin heavy chain complex with protein''
-
**[[2wbe]] – cKIF MD+FNL+Tubulin A+Tubulin B+AMPPNP – cow <br />
+
**[[2wbe]] – cKIF MD+FNL+Tubulin +AMPPNP – cow <br />
-
**[[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br />
+
**[[1ia0]] – KIF1A MD+Tubulin +ATP - pig<br />
-
**[[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br />
+
**[[3edl]] – cKIF MD+ Tubulin – Cryo EM<br />
-
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
+
**[[4hna]], [[4lnu]] – hKIF1 + Tubulin + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br />
-
**[[4uxy]] – hKIF1 MD + Tubulin A + Tubulin B + GDP + GTP – Cryo EM<br />
+
**[[4uxy]] – hKIF1 MD + Tubulin + GDP + GTP – Cryo EM<br />
-
**[[2p4n]] – hKIF+ Tubulin A+Tubulin B – EM docking<br />
+
**[[2p4n]] – hKIF+ Tubulin – EM docking<br />
 +
**[[5mio]] – hKIF2C MD + Tubulin <br />
**[[1mkj]] – hKIF MD+docked FNL<br />
**[[1mkj]] – hKIF MD+docked FNL<br />
 +
**[[3fm8]] – hKIF13B FHA domain + centaurin-α-1<br />
 +
**[[3md8]] – hKIF13B FHA domain + centaurin-α-1 + IP4<br />
 +
**[[3vhx]] – hKIF23 794-911 + ADP-ribosylation factor 6 <br />
**[[1n6m]] – DmKIF MD+FNL<br />
**[[1n6m]] – DmKIF MD+FNL<br />
-
**[[4atx]] - rKIF MD+ Tubulin A+Tubulin B – Cryo EM<br />
+
**[[4atx]] - rKIF MD+ Tubulin – Cryo EM<br />
-
**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin α-1A and β<br />
+
**[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin <br />
-
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin a-1A and b<br />
+
**[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin <br />
 +
**[[5nd3]] – mKIF20A MD + tubulin <br />
 +
**[[5nd2]], [[5nd4]] – mKIF20A MD + tubulin + ADP <br />
 +
**[[5nd7]] – mKIF20A MD + tubulin + AMPPNP <br />
 +
**[[5lef]] – mKIF20A residues 603-665 + RAB-6 <br />
*Kinesin light chain (KLC)
*Kinesin light chain (KLC)
Line 99: Line 119:
**[[4b7b]] - hKIF11 (mutant) + ADP + Co + Cd <br />
**[[4b7b]] - hKIF11 (mutant) + ADP + Co + Cd <br />
**[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg<br />
**[[3ken]], [[2wog]], [[2x2r]], [[2xae]], [[4bbg]] - hKIF11 +S-trityl-L-cysteine derivative + ADP + Mg<br />
 +
**[[3wpn]] - hKIF11 +inhibitor <br />
**[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]] - hKIF11+inhibitor +ADP + Mg<br />
**[[2uyi]], [[2uym]], [[2gm1]], [[2pg2]], [[2fme]], [[2x7d]], [[2x7c]], [[2ieh]], [[3cjo]], [[2g1q]], [[2fl2]], [[2fl6]], [[1yrs]], [[2q2y]], [[2fky]], [[2q2z]], [[3k3b]], [[2x7e]], [[4a50]], [[4a51]], [[3zcw]] - hKIF11+inhibitor +ADP + Mg<br />
-
**[[4bxn]] - hKIF11+inhibitor +ADP + Cd<br />
+
**[[4bxn]], [[4as7]] - hKIF11+inhibitor +ADP + Cd<br />
**[[3l9h]] - hKIF11+inhibitor +ADP <br />
**[[3l9h]] - hKIF11+inhibitor +ADP <br />
 +
**[[4zhi]] – hKIF11 MD +ADP<br />
**[[1x88]], [[1q0b]] - hKIF11 +Mg + ADP+monastrol <br />
**[[1x88]], [[1q0b]] - hKIF11 +Mg + ADP+monastrol <br />
**[[4ap0]], [[4a5y]] - hKIF11 +MgADP + ispinesib + Mg<br />
**[[4ap0]], [[4a5y]] - hKIF11 +MgADP + ispinesib + Mg<br />
**[[3hqd]] - hKIF11 +AMPPNP+Mg<br />
**[[3hqd]] - hKIF11 +AMPPNP+Mg<br />
**[[1ii6]], [[4a1z]], [[4a28]] - hKIF11 +ADP+Mg<br />
**[[1ii6]], [[4a1z]], [[4a28]] - hKIF11 +ADP+Mg<br />
 +
**[[4zca]] - hKIF11 (mutant) +ADP+Mg<br />
**[[3k5e]] - hKIF11 +ADP+enastrol + Mg<br />
**[[3k5e]] - hKIF11 +ADP+enastrol + Mg<br />
**[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br />
**[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br />
**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br />
-
**[[4pxt]], [[4pxu]] –DmKIF (mutant)<br />
+
**[[4pxt]], [[4pxu]] – DmKIF (mutant)<br />
 +
**[[5m5i]], [[5m5l]], [[5m5m]], [[5m5n]], [[5m5o]] – KIF + tubulin + GDP + GTP + ANP + axol – fission yeast – Cryo EM<br />
 +
 
 +
*Kinesin-6
 +
 
 +
**[[5x3e]] - KLP MD - Caenorhabditis elegans<br />
 +
 
 +
*Kinesin-8
 +
 
 +
**[[3lre]] - hKIF18A MD <br />
 +
**[[5oam]] - hKIF18A MD + tubulin + GTP<br />
 +
**[[5ocu]] - hKIF18A MD + tubulin + GTP + GDP + ANP<br />
 +
**[[5ogc]] - hKIF18A MD + tubulin + GTP + GDP + taxol<br />
*Kinesin-14
*Kinesin-14
-
**[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - Kar3 MD (mutant) - yeast<br />
+
**[[1f9t]], [[1f9u]], [[1f9v]], [[1f9w]], [[3kar]] - yKar3 MD (mutant) - yeast<br />
 +
**[[4etp]] - yKar3 MD (mutant) + VIK1<br />
**[[3l1c]] – DmNCD (mutant)
**[[3l1c]] – DmNCD (mutant)
 +
 +
*KCBP
 +
 +
**[[3h4s]] – KCBP+ADP+Mg – ''Arabidopsis thaliana''<br />
*NOD
*NOD

Revision as of 09:27, 21 December 2017

KIF1A Motor Domain complex with ADP and Mg+2 ion (green), 2zfi

Drag the structure with the mouse to rotate

3D Structures of Kinesin

Updated on 21-December-2017

References

  1. ↑ Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. PMID:19773780 doi:http://dx.doi.org/10.1038/nrm2774
  2. ↑ Ebbing B, Mann K, Starosta A, Jaud J, Schols L, Schule R, Woehlke G. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum Mol Genet. 2008 May 1;17(9):1245-52. doi: 10.1093/hmg/ddn014. Epub 2008 Jan, 18. PMID:18203753 doi:http://dx.doi.org/10.1093/hmg/ddn014
  3. ↑ Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003 Oct;28(10):558-65. PMID:14559185 doi:http://dx.doi.org/10.1016/j.tibs.2003.08.006
  4. ↑ Grosch M, Gruner B, Spranger S, Stutz AM, Rausch T, Korbel JO, Seelow D, Nurnberg P, Sticht H, Lausch E, Zabel B, Winterpacht A, Tagariello A. Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol. 2013 Oct-Nov;32(7-8):387-92. doi: 10.1016/j.matbio.2013.05.001. Epub, 2013 May 9. PMID:23665482 doi:http://dx.doi.org/10.1016/j.matbio.2013.05.001
  5. ↑ Nitta R, Okada Y, Hirokawa N. Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat Struct Mol Biol. 2008 Oct;15(10):1067-75. Epub 2008 Sep 21. PMID:18806800 doi:10.1038/nsmb.1487
Retrieved from "http://52.214.119.220/wiki/index.php/Kinesin"
Personal tools