This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Aminopeptidase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 47: Line 47:
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-AP + inhibitor <br />
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-AP + inhibitor <br />
-
**[[4fke]] – pAla-AP + Zn – pig<br />
+
**[[4fke]], [[5lds]], [[5lg6]] – pAla-AP + Zn – pig<br />
**[[4fkh]] – pAla-AP + Zn + alanine<br />
**[[4fkh]] – pAla-AP + Zn + alanine<br />
**[[4naq]], [[4nz8]] – pAla-AP + Zn + polyalanine<br />
**[[4naq]], [[4nz8]] – pAla-AP + Zn + polyalanine<br />
Line 67: Line 67:
**[[4q4i]] – EcAPN+ Zn + peptide<br />
**[[4q4i]] – EcAPN+ Zn + peptide<br />
**[[4q4e]] – EcAPN+ Zn + actinonin<br />
**[[4q4e]] – EcAPN+ Zn + actinonin<br />
-
**[[4ou3]] – pAPN+ Zn + peptide<br />
+
**[[5mfr]], [[5mfs]], [[5mft]] – EcAPN+ Zn + aminobenzosuberone<br />
 +
**[[4ou3]] – pAPN+ Zn + polypeptide<br />
 +
**[[6buy]], [[6bv0]], [[6bv1]], [[6bv2]], [[6bv3]], [[6bv4]] – pAPN+ Zn + amino acid<br />
 +
**[[5lhd]] – hAPN+ Zn <br />
 +
**[[6atk]] – hAPN+ Zn + spike glycoprotein<br />
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
**[[5dyf]] – NmAPN + benzyl-diaminoethylphosphonate<br />
**[[5dyf]] – NmAPN + benzyl-diaminoethylphosphonate<br />
Line 75: Line 79:
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[4fgm]] – AP N + Zn – ''Idiomarina loihiensis''<br />
**[[4fgm]] – AP N + Zn – ''Idiomarina loihiensis''<br />
 +
 +
*Aminopeptidase P
 +
 +
**[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br />
*Proline aminopeptidase
*Proline aminopeptidase
Line 107: Line 115:
**[[3azp]] - SmPro-AP (mutant)<br />
**[[3azp]] - SmPro-AP (mutant)<br />
**[[3azq]] - SmPro-AP (mutant) + PGG<br />
**[[3azq]] - SmPro-AP (mutant) + PGG<br />
 +
**[[4s2r]] – CePro-AP 1 + Zn - ''Caenorhabditis elegans'' <br />
 +
**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br />
*Leucine aminopeptidase
*Leucine aminopeptidase
Line 115: Line 125:
**[[5jh9]] – yLeu-AP 1 (mutant) + Zn<br />
**[[5jh9]] – yLeu-AP 1 (mutant) + Zn<br />
**[[3jru]] – Leu-AP – ''Xanthomonas oryzae''<br />
**[[3jru]] – Leu-AP – ''Xanthomonas oryzae''<br />
-
**[[2hc9]], [[2hb6]] – Leu-AP – ''Caenorhabditis elegans''<br />
+
**[[2hc9]], [[2hb6]] – CeLeu-AP <br />
**[[2ewb]] – bLeu-AP+zofenoprilat – bovine<br />
**[[2ewb]] – bLeu-AP+zofenoprilat – bovine<br />
**[[1lam]], [[1lap]] – bLue-AP<br />
**[[1lam]], [[1lap]] – bLue-AP<br />
Line 148: Line 158:
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
 +
**[[5ntg]], [[5ntf]] – Leu-AP – ''Trypanosoma cruzi''<br />
 +
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
 +
**[[5gne]] – Leu-AP + Zn – ''Legionella pneumophila''<br />
*Leucine-cysteine aminopeptidase
*Leucine-cysteine aminopeptidase
-
**[[4p8q]], [[5c97]] – hLeu-Cys-AP + Zn<br />
+
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
Line 167: Line 180:
**[[4fo7]], [[4juq]] - PaMet-AP+Mn – ''Pseudomonas aeruginosa''<br />
**[[4fo7]], [[4juq]] - PaMet-AP+Mn – ''Pseudomonas aeruginosa''<br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
-
**[[4hxx]], [[4iu6]] - hMet-AP 1 + Co + pyrimidine derivative<br />
 
-
**[[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]] - hMet-AP 1 +Mn+inhibitor<br />
 
-
**[[2b3h]], [[2b3k]] - hMet-AP 1 +Co<br />
 
-
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]] – hMet-AP 1 +Co+inhibitor<br />
 
-
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
 
-
**[[2ea2]], [[2ea4]], [[2ga2]] - hMet-AP 2 +Mn+inhibitor<br />
 
-
**[[1boa]] - hMet-AP 2 +Co+ angiogenesis inhibitor<br />
 
-
**[[1kq0]], [[1kq9]] – hMet-AP 2 +methionine<br />
 
-
**[[1qzy]], [[1b59]], [[1b6a]], [[1bn5]], [[2oaz]], [[5d6f]], [[5d6e]] - hMet-AP 2 +Co+inhibitor<br />
 
-
**[[2adu]] - hMet-AP 2 (mutant) +Co+inhibitor<br />
 
-
**[[1r58]], [[1r5g]], [[1r5h]] - hMet-AP 2 +Mn+inhibitor<br />
 
**[[3iu7]] – MtMet-AP+Mn +A02 – ''Mycobacterium tuberculosis''<br />
**[[3iu7]] – MtMet-AP+Mn +A02 – ''Mycobacterium tuberculosis''<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
Line 183: Line 185:
**[[3pka]] - MtMet-AP+Mn<br />
**[[3pka]] - MtMet-AP+Mn<br />
**[[3pkb]], [[3pkc]], [[3pkd]], [[3pke]] - MtMet-AP+bengamide inhibitor<br />
**[[3pkb]], [[3pkc]], [[3pkd]], [[3pke]] - MtMet-AP+bengamide inhibitor<br />
-
**[[3tav]] – Met-AP + Mg – ''Mycobacterium abscessus''< br />
 
**[[1y1n]] - MtMet-AP+K<br />
**[[1y1n]] - MtMet-AP+K<br />
**[[4idy]], [[4iec]] - MtMet-AP+K + hydroxyethyl disulfide<br />
**[[4idy]], [[4iec]] - MtMet-AP+K + hydroxyethyl disulfide<br />
Line 199: Line 200:
**[[2mat]], [[4mat]], [[4u76]], [[4u75]], [[4u73]], [[4u71]], [[4u70]], [[4u6z]], [[4u6w]], [[4u6j]], [[4u6e]], [[4u6c]], [[4u76]], [[4u1b]] - EcMet-AP 1 (mutant)+Co<br />
**[[2mat]], [[4mat]], [[4u76]], [[4u75]], [[4u73]], [[4u71]], [[4u70]], [[4u6z]], [[4u6w]], [[4u6j]], [[4u6e]], [[4u6c]], [[4u76]], [[4u1b]] - EcMet-AP 1 (mutant)+Co<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
-
**[[4fli]], [[4flj]], [[4flk]], [[4fll]] - hMet-AP 1 +Mn+inhibitor<br />
 
**[[1qxw]], [[1qxy]], [[1qxz]] – Met-AP+Co+inhibitor - ''Staphylococcus aureus''<br />
**[[1qxw]], [[1qxy]], [[1qxz]] – Met-AP+Co+inhibitor - ''Staphylococcus aureus''<br />
**[[1o0x]] – TmMet-AP<br />
**[[1o0x]] – TmMet-AP<br />
**[[3s6b]] – PfMet-AP + Fe <br />
**[[3s6b]] – PfMet-AP + Fe <br />
-
**[[4fuk]] – TbMet-AP + Zn – ''Trypanosoma brucei''<br />
+
**[[4fuk]] – TbMet-AP + Zn <br />
**[[4km3]] – SpAP<br />
**[[4km3]] – SpAP<br />
 +
**[[3tav]] – Met-AP + Mg – ''Mycobacterium abscessus''< br />
 +
 +
*Human methionine aminopeptidase
 +
 +
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
 +
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]] – hMet-AP 1 + Co + inhibitor<br />
 +
**[[4fli]], [[4flj]], [[4flk]], [[4fll]], [[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]] - hMet-AP 1 + Mn +inhibitor<br />
 +
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
 +
**[[1boa]] - hMet-AP 2 +Co+ angiogenesis inhibitor<br />
 +
**[[1kq0]], 1kq9]] – hMet-AP 2 +methionine<br />
 +
**[[1qzy]], [[1b59]], [[1b6a]], [[1bn5]], [[2oaz]], [[5d6f]], [[5d6e]], [[5cls]] - hMet-AP 2 +Co+inhibitor<br />
 +
**[[2adu]] - hMet-AP 2 (mutant) +Co+inhibitor<br />
 +
**[[5lyw]], [[5lyx]] - hMet-AP 2 (mutant) + Zn + inhibitor<br />
 +
**[[1r58]], [[1r5g]], [[1r5h]], [[5ji6]], [[5jhu]], [[5jfr]], [[5cls]], [[4z7m]], [[5jhu]], [[5jfr]], [[2ea2]], [[2ea4]], [[2ga2]], [[5lyw]] - hMet-AP 2 +Mn+inhibitor<br />
*Arginine aminopeptidase
*Arginine aminopeptidase
Line 234: Line 248:
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''
-
*Aminopeptidase 2
+
*Endoplasmic reticulum aminopeptidase
-
**[[3se6]] – hAPN<br />
+
**[[5j5e]] – hARTS-1 ERAP1 domain<br />
-
**[[4e36]] – hAPN + Zn
+
**[[3se6]] – hARTS-2<br />
 +
**[[4e36]] – hARTS-2 + Zn<br />
 +
**[[5k1v]], [[5j6s]] – hARTS-2 + Zn + inhibitor<br />
*Non-specific aminopeptidase
*Non-specific aminopeptidase
Line 291: Line 307:
**[[3n5i]] – SxBapA (mutant)<br />
**[[3n5i]] – SxBapA (mutant)<br />
**[[3n33]] – SxBapA + AEBSF<br />
**[[3n33]] – SxBapA + AEBSF<br />
-
**[[3ndv]], [[3nfb]] – SxBapA + ampicillin
+
**[[3ndv]], [[3nfb]] – SxBapA + ampicillin<br />
 +
**[[5tzb]] - AP – ''Burkholderia''<br />
*M1 family aminopeptidase
*M1 family aminopeptidase

Revision as of 09:30, 13 March 2018

Bacterial leucine aminopeptidase complex with 8-hydroxyquinoline, glycerol, SCN, Zn+2 (magenta), Na+ (cyan) and Cl- (green) ions (PDB code 3vh9)

Drag the structure with the mouse to rotate

3D Structures of Aminopeptidase

Updated on 13-March-2018

Additional Resources

For additional information, see:
Amino Acid Synthesis & Metabolism
Streptomyces griseus Aminopeptidase (SGAP)

References

  1. ↑ Taylor A. Aminopeptidases: structure and function. FASEB J. 1993 Feb 1;7(2):290-8. PMID:8440407
  2. ↑ Hanaya K, Suetsugu M, Saijo S, Yamato I, Aoki S. Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn(2+) fluorophores, kinetic, and X-ray crystallographic study. J Biol Inorg Chem. 2012 Feb 5. PMID:22311113 doi:10.1007/s00775-012-0873-4

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Eran Hodis

Retrieved from "http://52.214.119.220/wiki/index.php/Aminopeptidase"
Personal tools