1yd9
From Proteopedia
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'''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.''' | '''1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.''' | ||
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[[Category: Perche, P Y.]] | [[Category: Perche, P Y.]] | ||
[[Category: Swamy, G Y.S K.]] | [[Category: Swamy, G Y.S K.]] | ||
| - | [[Category: | + | [[Category: A1pp domain]] |
| - | [[Category: | + | [[Category: Alpha-beta structure]] |
| - | [[Category: | + | [[Category: Macro-domain]] |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:10, 3 May 2008
1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.
Overview
macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
About this Structure
1YD9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708 Page seeded by OCA on Sat May 3 16:10:49 2008
