1yfe

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[[Image:1yfe.gif|left|200px]]
[[Image:1yfe.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1yfe |SIZE=350|CAPTION= <scene name='initialview01'>1yfe</scene>, resolution 2.19&Aring;
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The line below this paragraph, containing "STRUCTURE_1yfe", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span>
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{{STRUCTURE_1yfe| PDB=1yfe | SCENE= }}
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|RELATEDENTRY=[[1fuo|1FUO]], [[1fup|1FUP]], [[1fuq|1FUQ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yfe OCA], [http://www.ebi.ac.uk/pdbsum/1yfe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yfe RCSB]</span>
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}}
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'''Crystal structure of apo fumarase C from Escherichia coli'''
'''Crystal structure of apo fumarase C from Escherichia coli'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Weaver, T.]]
[[Category: Weaver, T.]]
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[[Category: allosteric]]
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[[Category: Allosteric]]
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[[Category: apo]]
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[[Category: Apo]]
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[[Category: fumarase]]
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[[Category: Fumarase]]
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[[Category: kreb's cycle]]
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[[Category: Kreb's cycle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:15:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:05:32 2008''
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Revision as of 13:15, 3 May 2008

Image:1yfe.gif

Template:STRUCTURE 1yfe

Crystal structure of apo fumarase C from Escherichia coli


Overview

Previous crystal structures of fumarase C from Escherichia coli have noted two occupied dicarboxylate-binding sites termed the active site and the B site. Here, the first known fumarase C structure is reported in which both sites are unoccupied by bound ligand. This so-called ;free' crystal form shows conservation of the active-site water in a similar orientation to that reported in other fumarase C crystal structures. More importantly, a shift of His129 has been observed at the B site. This new crystallographic information suggests the use of water as a permanent member of the active site and the use of an imidazole-imidazolium conversion to control access at the allosteric B site.

About this Structure

1YFE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of free fumarase C from Escherichia coli., Weaver T, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1395-401. Epub, 2005 Sep 28. PMID:16204892 Page seeded by OCA on Sat May 3 16:15:17 2008

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