1ygy

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[[Image:1ygy.gif|left|200px]]
[[Image:1ygy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ygy |SIZE=350|CAPTION= <scene name='initialview01'>1ygy</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1ygy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </span>
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|GENE= serA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00389 2-Hacid_dh], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02826 2-Hacid_dh_C], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04902 ACT_3PGDH-xct]</span>
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{{STRUCTURE_1ygy| PDB=1ygy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ygy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ygy OCA], [http://www.ebi.ac.uk/pdbsum/1ygy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ygy RCSB]</span>
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'''Crystal Structure of D-3-Phosphoglycerate dehydrogenase From Mycobacterium tuberculosis'''
'''Crystal Structure of D-3-Phosphoglycerate dehydrogenase From Mycobacterium tuberculosis'''
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[[Category: Sacchettini, J C.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: phosphoglycerate dehydrogenase]]
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[[Category: Phosphoglycerate dehydrogenase]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: serine biosynthesis]]
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[[Category: Serine biosynthesis]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tb structural genomics consortium]]
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[[Category: Tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:18:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:06:54 2008''
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Revision as of 13:18, 3 May 2008

Image:1ygy.gif

Template:STRUCTURE 1ygy

Crystal Structure of D-3-Phosphoglycerate dehydrogenase From Mycobacterium tuberculosis


Overview

Phosphoglycerate dehydrogenases exist in at least three different structural motifs. The first D-3-phosphoglycerate dehydrogenase structure to be determined was from Escherichia coli and is a tetramer composed of identical subunits that contain three discernable structural domains. The crystal structure of D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis has been determined at 2.3 A. This enzyme represents a second structural motif of the D-3-phosphoglycerate dehydrogenase family, one that contains an extended C-terminal region. This structure is also a tetramer of identical subunits, and the extended motif of 135 amino acids exists as a fourth structural domain. This intervening domain exerts quite a surprising characteristic to the structure by introducing significant asymmetry in the tetramer. The asymmetric unit is composed of two identical subunits that exist in two different conformations characterized by rotation of approximately 180 degrees around a hinge connecting two of the four domains. This asymmetric arrangement results in the formation of two different and distinct domain interfaces between identical domains in the asymmetric unit. As a result, the surface of the intervening domain that is exposed to solvent in one subunit is turned inward in the other subunit toward the center of the structure where it makes contact with other structural elements. Significant asymmetry is also seen at the subunit level where different conformations exist at the NAD-binding site and the putative serine-binding site in the two unique subunits.

About this Structure

1YGY is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits., Dey S, Grant GA, Sacchettini JC, J Biol Chem. 2005 Apr 15;280(15):14892-9. Epub 2005 Jan 24. PMID:15668249 Page seeded by OCA on Sat May 3 16:18:13 2008

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