1yhp

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[[Image:1yhp.gif|left|200px]]
[[Image:1yhp.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1yhp", creates the "Structure Box" on the page.
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|GENE= cadA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhp OCA], [http://www.ebi.ac.uk/pdbsum/1yhp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yhp RCSB]</span>
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'''Solution Structure of Ca2+-free DdCAD-1'''
'''Solution Structure of Ca2+-free DdCAD-1'''
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[[Category: Siu, C H.]]
[[Category: Siu, C H.]]
[[Category: Yang, D W.]]
[[Category: Yang, D W.]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: ddcad-1]]
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[[Category: Ddcad-1]]
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[[Category: nmr]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:19:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:07:32 2008''
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Revision as of 13:19, 3 May 2008

Image:1yhp.gif

Template:STRUCTURE 1yhp

Solution Structure of Ca2+-free DdCAD-1


Overview

DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.

About this Structure

1YHP is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715 Page seeded by OCA on Sat May 3 16:19:49 2008

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