1yi8

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[[Image:1yi8.gif|left|200px]]
[[Image:1yi8.gif|left|200px]]
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{{Structure
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|PDB= 1yi8 |SIZE=350|CAPTION= <scene name='initialview01'>1yi8</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1yi8", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>
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|GENE= DR1093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1])
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{{STRUCTURE_1yi8| PDB=1yi8 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yi8 OCA], [http://www.ebi.ac.uk/pdbsum/1yi8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yi8 RCSB]</span>
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'''Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp'''
'''Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp'''
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[[Category: Buddha, M R.]]
[[Category: Buddha, M R.]]
[[Category: Crane, B R.]]
[[Category: Crane, B R.]]
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[[Category: auxiliary tryptophanyl trna synthetase]]
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[[Category: Auxiliary tryptophanyl trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:20:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:08:04 2008''
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Revision as of 13:20, 3 May 2008

Image:1yi8.gif

Template:STRUCTURE 1yi8

Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp


Overview

The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.

About this Structure

1YI8 is a Single protein structure of sequence from Deinococcus radiodurans r1. Full crystallographic information is available from OCA.

Reference

Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:15723076 Page seeded by OCA on Sat May 3 16:20:56 2008

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